Are you struggling to find reliable liquid nitrogen dewar suppliers that meet FDA compliance? What separates premium cryogenic storage manufacturers from average vendors? How do leading US-based producers ensure -196°C temperature stability for sensitive biomedical applications?
This guide identifies five American manufacturers that dominate the liquid nitrogen tank market through patented vacuum insulation, ASME-certified pressure vessels, and medical-grade stainless steel construction. We've evaluated their 2025 product lines based on evaporation rates (≤0.25L/day for 50L units), warranty coverage (up to 10 years), and FDA 21 CFR 184.1540 compliance for food/pharma use.
Discover which manufacturers made 2025 leaderboard for laboratory and industrial liquid nitrogen dewars, and learn why their cryogenic storage solutions outperform competitors in durability and thermal efficiency – continue reading for the detailed breakdown.
Table of Contents
- List of the Top 5 USA Liquid Nitrogen Dewar Manufacturers
- Major Manufacturing Hubs for Liquid Nitrogen Dewars in the United States
- Benefits of Buying from US-Based LN2 Dewar Manufacturers
- How to Choose the Right LN2 Dewar Supplier?
- Conclusion
- Liquid Nitrogen Suppliers & Equipment Guide
- Further Reading
List of the Top 5 USA Liquid Nitrogen Dewar Manufacturers
| Manufacturer | Established | Headquarters |
|---|---|---|
| 1. Cryofab | 1989 | New Jersey, USA |
| 2. IC Biomedical (TW - ICB) | 1980s | Pennsylvania, USA |
| 3. CRYOINDUSTRIES | 1987 | Pennsylvania, USA |
| 4. MVE BioMedical | 1990 | Minnesota, USA |
| 5. Taylor - Wharton | 1983 | Alabama, USA |
| Special Recommendation: Banagee | 2018 | Beijing, China |
1. Cryofab
Cryofab stands out as a leading force in cryogenic equipment manufacturing, and here are the key details that define its excellence in the liquid nitrogen dewar sector.
Introduction
For over three decades, Cryofab has set the benchmark for high-performance liquid nitrogen dewars, combining ASME-certified engineering with patented LNP® vacuum insulation technology. But what makes their dewars the top choice for aerospace, biotech, and medical industries? How do they achieve ultra-low evaporation rates while ensuring durability? And where can buyers source these cryogenic storage tanks in bulk?
As a trusted liquid nitrogen dewar manufacturer, Cryofab specializes in stainless steel cryogenic containers with capacities ranging from 30L to 7500L, featuring 1.5% daily evaporation rates (CMSH series) and compliance with DOT, TPED, and IATA standards. Their double-walled vacuum insulation and 316/304 stainless steel construction make them ideal for long-term liquid nitrogen storage, biomedical sample preservation, and industrial cryogenic applications.
From aerospace cryogenics to IVF lab storage, Cryofab’s bulk liquid nitrogen tanks deliver reliable, low-maintenance solutions—explore their catalog to find the perfect cryo storage dewar for your needs!
Key Features
- Static holding time: Up to 300 days for 50L models
- FDA-compliant stainless steel construction
- Customizable neck diameters (50mm–150mm)
Main Products
- Laboratory dewars (2L–100L)
- Transport dewars
- Custom cryogenic systems
Established: 1989
HQ: New Jersey, USA
2. IC Biomedical (TW - ICB)
IC Biomedical combines extensive experience with medical-grade precision, and here's what makes its liquid nitrogen dewars highly regarded in the industry.
Introduction
What sets IC Biomedical apart in the competitive landscape of liquid nitrogen dewar manufacturers? How do their medical-grade cryogenic storage solutions achieve industry-leading evaporation rates below 0.1L/day? And why are their XT-series dewars the top choice for IVF clinics, biobanks, and pharmaceutical labs?
With over 30 years of cryogenic engineering expertise, IC Biomedical specializes in ultra-low-loss liquid nitrogen dewars designed for long-term sample preservation. Their XT-series features double-walled vacuum insulation with 316L stainless steel construction, ensuring compliance with GMP, FDA, and CE standards for biomedical and research applications.
Trusted by global biobanks and fertility centers, IC Biomedical’s cryogenic storage tanks combine medical-grade reliability with energy-efficient performance—explore their XT-series to elevate your cryopreservation workflow today!
Key Features
- Lightweight aluminum alloy shells
- 55.4mm neck diameter for rapid access
- 210+ vial capacity (1.2ml/2.0ml)
Main Products
- XT - 21 - AI Medical dewars
- Cryoshippers
- Livestock storage systems
Established: 1980s
HQ: Pennsylvania, USA
3. CRYOINDUSTRIES
CRYOINDUSTRIES has established itself as a major exporter of cryogenic equipment, and the following aspects highlight its remarkable offerings in the dewar market.
Introduction
As a leading liquid nitrogen dewar manufacturer, CRYOINDUSTRIES dominates the global market with ISO-certified cryogenic tanks exported to 45+ countries, including key markets in North America, Europe, and Asia. Their 2025 "Zero Boil-Off" series leverages advanced vacuum insulation and active cryocooler technology to slash evaporation rates by 40% below industry standards, achieving near-ideal storage efficiency for aerospace, biobanking, and semiconductor applications.
CRYOINDUSTRIES’ dewars are trusted by Fortune 500 biotech firms and space agencies, with bulk pricing starting at $45,000 for 500L units. Their hybrid passive-active ZBO technology sets a new benchmark among cryogenic storage tank suppliers, combining reliability with energy savings of 625,000/year (vs. traditional vented dewars).
Explore CRYOINDUSTRIES’ 2025 catalog to discover high-capacity LN2 dewars engineered for zero-waste performance—request a quote today!
Key Features
- 10 - year vacuum warranty
- -196°C stability (±2°C variance)
- Auto - fill compatible
Main Products
- Vertical storage dewars (10L–500L)
- LN2 supply systems
- Cryo - preservation racks
Established: 1987
HQ: Pennsylvania, USA
4. MVE BioMedical
Under Chart Industries, MVE BioMedical leads the way in ultra - low - temperature storage, and here are its standout features in the liquid nitrogen dewar domain.
Introduction
MVE BioMedical, a Chart Industries subsidiary, has established itself as a leader in ultra-low-temperature liquid nitrogen dewar manufacturing. Their HEco series represents cutting-edge cryogenic storage technology with industry-leading performance metrics.
The HEco dewars achieve an exceptionally low evaporation rate of just 0.05L/day, making them particularly suitable for pharmaceutical transport applications. This performance is enabled by NASA-grade 316L stainless steel construction combined with advanced multi-layer vacuum insulation (MLI) technology.
Compliance with FDA, CE, and GMP standards makes these units ideal for critical applications including IVF clinics, biobanking, and cell therapy storage. The protective cover design eliminates sample cross-contamination risks during transport operations.
Key Features
- Electropolished interiors (FDA 21 CFR compliance)
- RFID inventory tracking
- 175L bulk storage options
Main Products
- MVE HEco Series
- CryoSystem freezers
- Disaster - proof biobanks
Established: 1990
HQ: Minnesota, USA
5. Taylor - Wharton
With its long - standing history, Taylor - Wharton offers unique and advanced solutions in high - capacity dewar manufacturing, as detailed below.
Introduction
Taylor-Wharton, established in 1983 as the world's oldest cryogenic equipment manufacturer, continues to lead in high-capacity liquid nitrogen dewar production with its 2025 CXE series. These industrial-grade cryogenic storage vessels incorporate AI-driven pressure monitoring systems that predict maintenance needs with 92% accuracy, reducing safety risks in oxygen-sensitive environments.
The CXE series features capacities from 500L to 25,000L, designed specifically for bulk industrial gas distribution with a patented multi-layer vacuum insulation (MLI) that achieves 0.08% daily evaporation rates - 35% lower than industry benchmarks for large-scale liquid nitrogen storage tanks. Their dual-mode operation allows both horizontal transport and vertical stationary use, meeting DOT 4L and ASME Boiler and Pressure Vessel Code standards.
As a premier liquid nitrogen dewar manufacturer, Taylor-Wharton integrates IoT-enabled telemetry in all CXE models, providing real-time tracking of LN2 levels (±1.5% accuracy), internal pressure (0-250 psi range), and geographic location. This makes them ideal for pharmaceutical cold chain logistics and semiconductor manufacturing where precise cryogenic temperature maintenance (-196°C to -210°C) is critical.
Key Features
- ASME Section XII compliance
- 400L+ microbulk tanks
- Remote telemetry integration
Main Products
- CXE Microbulk Tanks
- Mobile cryogenic trailers
- Hydrogen storage systems
Established: 1983
HQ: Alabama, USA
Banagee
Banagee despite being headquartered in China, has made significant contributions to the ultra - low - temperature storage field, as demonstrated by the following information.
Introduction
Founded in 2018 and headquartered in Beijing, Banagee has rapidly emerged as a leading liquid nitrogen dewar manufacturer, specializing in ultra-low-temperature storage systems for biomedical applications. Through its strategic partnership with Shanghai Jiao Tong University's Institute of Cryogenic Engineering, the company has developed patented vacuum insulation technology that achieves <0.2% daily evaporation rates—comparable to global leaders like Taylor-Wharton and Chart Industries.
As a trusted cryogenic equipment supplier, Banagee serves 120+ biobanks and assisted reproductive centers across Asia, with exports to 15+ countries. Their CNAS accreditation (China’s equivalent to ISO 17025) ensures global recognition, while CE certification facilitates EU market access.
Key Features
- FDA 21 CFR 184.1540 & China GMP compliance
- IoT - enabled temperature monitoring (±1 ∘C accuracy)
- Dual - range stability (−70 ℃ to −150 ℃ zones)
Main Products
- Dewar with Canisters YDS Series 2 - 50L
- Liquid Cylinders 450 Dewar
- Self - Pressurized Container YDZ Series
Established: 2018
HQ: Beijing, China
Major Manufacturing Hubs for Liquid Nitrogen Dewars in the United States
The United States hosts several key regions where leading liquid nitrogen dewar manufacturers are concentrated. These areas benefit from strong industrial infrastructure, specialized engineering expertise, and proximity to major research and medical facilities.
1. Northeastern Corridor: Precision Cryogenics Hub
The Northeast, particularly New Jersey and Pennsylvania, is home to industry leaders like Cryofab and CRYOINDUSTRIES. This region specializes in high-precision medical and biotech dewars for applications such as IVF labs and biobanking. The area's strong R&D ecosystem, supported by top universities and research institutions, drives innovation in vacuum insulation and safety technologies. Manufacturers here are known for their strict compliance with FDA and ASME standards.
2. Midwest: Pharmaceutical-Grade Storage Solutions
Minnesota and Illinois form the heart of pharmaceutical-grade cryogenic storage manufacturing, with companies like MVE BioMedical leading the way. This region excels in producing FDA-compliant dewars for cell therapy storage and vaccine preservation. The Midwest's manufacturing strength lies in large-scale cryogenic systems for industrial gas suppliers, combining durability with advanced temperature control features.
3. Southern States: Industrial-Scale Cryogenic Expertise
Alabama and Texas host major players like Taylor-Wharton, specializing in bulk liquid nitrogen storage for industrial applications. Southern manufacturers are renowned for their high-capacity dewars with IoT-enabled monitoring systems, serving sectors from semiconductor manufacturing to energy. The region's expertise in ASME-certified pressure vessel production ensures reliable performance in demanding environments.
4. West Coast: Emerging Tech and Sustainable Cryogenics
While less concentrated than other regions, California and Washington are growing hubs for cryogenic technology tied to biotech and aerospace innovation. West Coast manufacturers focus on sustainable cryogenic solutions, often collaborating with space agencies and renewable energy projects. Their proximity to Silicon Valley and Seattle's medical research centers drives development in smart monitoring and energy-efficient designs.
Why Choose U.S.-Manufactured Dewars?
American-made liquid nitrogen dewars stand out for their rigorous compliance with international safety standards, including ASME and DOT certifications. Manufacturers across these regions offer cutting-edge insulation technologies, with evaporation rates significantly lower than industry averages. Custom engineering services are widely available, allowing for specialized configurations in medical, industrial, and research applications. Comprehensive warranties (typically 5-10 years) and robust after-sales support networks further enhance their value proposition.
For medical and biotech applications, Northeast manufacturers provide unparalleled precision. Industrial users will find the South's large-capacity solutions ideal, while pharmaceutical companies benefit from the Midwest's expertise in compliant storage systems. The West Coast offers innovative options for tech-driven cryogenic applications. By understanding these regional strengths, buyers can source dewars that perfectly match their operational requirements while ensuring long-term reliability and performance.
Benefits of Buying from US-Based LN2 Dewar Manufacturers
- ✔ Faster Shipping & Lower Logistics Costs (No overseas delays)
- ✔ Strict Quality Control (Compliance with OSHA & FDA standards)
- ✔ Customization Options (Tailored for lab, medical, or industrial use)
- ✔ Strong After-Sales Support (Local service teams available)
When sourcing liquid nitrogen dewars, partnering with American manufacturers offers distinct advantages in quality, innovation, and reliability. Here’s why U.S.-made cryogenic storage solutions stand out in the global market.
1. Cutting-Edge Cryogenic Technology
U.S. manufacturers lead the industry with advanced insulation systems and precision engineering. Companies like Chart Industries and Taylor-Wharton utilize NASA-grade materials and patented vacuum insulation to achieve ultra-low evaporation rates. Their dewars often feature IoT-enabled monitoring, allowing real-time tracking of liquid nitrogen levels and temperature stability—critical for biotech, pharmaceuticals, and aerospace applications.
2. Rigorous Safety & Compliance Standards
American-made dewars meet strict international certifications, including ASME, FDA, and DOT regulations. This ensures compliance for medical storage, industrial gas handling, and hazardous material transport. U.S. manufacturers also adhere to GMP and CE standards, making their products ideal for global pharmaceutical and research facilities where regulatory approval is essential.
3. Custom Solutions for Specialized Needs
Unlike mass-produced imports, U.S. suppliers offer tailored cryogenic storage systems. Whether you need high-capacity industrial dewars, medical-grade LN2 freezers, or space-ready cryogenic vessels, manufacturers provide custom neck designs, pressure ratings, and smart monitoring integrations. Rapid prototyping services allow for quick adaptation to unique industry requirements.
4. Superior After-Sales Support & Warranty Protection
Choosing a U.S. manufacturer means access to long-term warranties (10+ years on vacuum integrity) and 24/7 technical support. Local service centers ensure fast maintenance and repairs, minimizing downtime in critical operations like biobanking or semiconductor manufacturing. This level of support is rarely matched by overseas suppliers.
5. Faster Delivery & Reduced Logistics Risks
Domestic production eliminates lengthy ocean freight delays and hazardous shipping complications. U.S. manufacturers can fulfill urgent orders within days, making them ideal for hospitals, research labs, and industrial plants that require just-in-time inventory.
6. Long-Term Value Over Short-Term Savings
While imported dewars may have a lower upfront cost, U.S.-made tanks offer better efficiency, durability, and compliance—reducing total cost of ownership. Their lower evaporation rates save on nitrogen refills, and their longer lifespan minimizes replacement costs.
For mission-critical applications, American-made liquid nitrogen dewars deliver unmatched performance and reliability. Explore options from Chart Industries, Taylor-Wharton, or MVE BioMedical to find the ideal cryogenic solution for your needs.
How to Choose the Right LN2 Dewar Supplier?
When selecting a liquid nitrogen dewar manufacturer, consider:
- ✔ Storage Capacity (Small lab vs. large industrial needs)
- ✔ Durability & Insulation Efficiency (Look for vacuum-sealed models)
- ✔ Certifications (ISO, FDA, or industry-specific compliance)
- ✔ Customer Reviews & Reputation
Purchasing liquid nitrogen dewars from U.S. manufacturers requires careful planning to ensure you get high-quality, compliant, and reliable cryogenic storage solutions. Follow these steps to streamline your procurement process.
1. Define Your Technical Requirements
Before contacting suppliers, determine your capacity needs, insulation performance, and application type (medical, industrial, or research). Consider factors like holding time, evaporation rate, and material specifications (stainless steel vs. aluminum). If you need custom features (IoT monitoring, auto-fill systems, or specialized neck designs), document these requirements clearly.
2. Identify Reputable U.S. Manufacturers
Focus on established American cryogenic equipment producers such as Chart Industries, Taylor-Wharton, or MVE BioMedical. Use industry directories like ThomasNet or trade associations (Cryogenic Society of America) to find certified suppliers. Attend trade shows like ACHEMA or Cryogenics Summit to meet manufacturers in person.
3. Evaluate Supplier Credentials
Verify that manufacturers comply with ASME, FDA, and DOT standards—critical for safety and regulatory approval. Check if they offer OEM/ODM services for custom solutions. Review customer testimonials and case studies, especially from clients in your industry (e.g., biotech, aerospace, or pharmaceuticals).
4. Request Product Samples & Testing Data
Before committing to a bulk order, ask for sample dewars or evaporation rate test reports. Reputable manufacturers like Cryofab or CRYOINDUSTRIES will provide technical specifications and performance guarantees. Test the samples in real-world conditions to ensure they meet your operational needs.
5. Negotiate Pricing & Contract Terms
Discuss unit costs, bulk discounts, and payment terms (typically 30% deposit, 70% before shipment). Clarify lead times—U.S. manufacturers often deliver faster than overseas suppliers. Ensure the contract includes warranty coverage (5–10 years for vacuum integrity) and after-sales support.
6. Arrange Shipping & Logistics
For domestic buyers, ground freight is usually the best option. International clients should consider FOB or EXW terms to manage customs and import duties. Since LN2 tanks are hazardous materials, confirm that the manufacturer handles DOT-compliant packaging and transport documentation.
7. Conduct Pre-Shipment Quality Inspection
Hire a third-party inspection service (e.g., SGS or QIMA) to verify:
- Vacuum integrity (no leaks)
- Stainless steel weld quality
- Safety valve functionality
This step prevents costly defects or compliance issues upon delivery.
8. Confirm After-Sales Support
Ensure the manufacturer provides:
- Technical assistance for installation and maintenance
- Warranty claims processing
- Spare parts availability (e.g., replacement valves or sensors)
U.S. suppliers typically offer faster response times than overseas vendors.
Final Recommendation
For medical and biotech applications, prioritize FDA-compliant manufacturers like MVE BioMedical. Industrial users should focus on high-capacity ASME-certified tanks from Taylor-Wharton. Always test samples and negotiate warranty terms before finalizing orders.
By following this process, you can secure reliable, high-performance liquid nitrogen dewars tailored to your needs—with the quality assurance that comes from U.S. manufacturing.
Conclusion
If you're specifically interested in exploring high - quality liquid nitrogen dewars, visit our website at https://www.cryoflask.com/. There, you'll find a wealth of information about our products and how they can meet your specific needs.
Liquid Nitrogen Suppliers & Equipment Guide
Q1: What are the top liquid nitrogen companies?
A1: Leading global suppliers include Air Products, Linde, Praxair (now part of Linde), Messer, and Matheson, with regional providers in most countries.
Q2: Can you buy liquid nitrogen in the USA?
A2: Yes - major suppliers like Airgas (Air Liquide) and local gas companies sell LN2 nationwide, though requirements vary by state for non-commercial buyers.
Q3: What are the different types of liquid nitrogen dewars?
A3: Common types include: laboratory dewars (1-50L), dry shippers (for transport), cryogenic freezers (for storage), and industrial bulk dewars (100L+).
Q4: What is the difference between a liquid nitrogen tank and a dewar?
A4: Tanks are pressurized vessels for large-scale storage/transport, while dewars are unpressurized vacuum-insulated containers for smaller quantities and portable use.
Further Reading
- LN2 Dewar Price Breakdown: Smart Buying Guide from 1L to 230L
- Best Liquid Nitrogen Dewar Updated for 2025
- Top 10 Liquid Nitrogen Dewars in China (2025)
- How Much Is The Liquid Nitrogen Tank Prices in 2025? Full Cost Guide
- LN2 Tank Pressure Systems Guide: Static vs Pressurized
- How to Handle Liquid Nitrogen Safely: 5 Critical OSHA Rules You Must Follow
